Disposition of sodium valproate in epileptic patients.
نویسندگان
چکیده
منابع مشابه
Sodium valproate in the treatment of the intractable childhood epileptic.
Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children's Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate). All types of seizure disorders were included in the group. Rapid oral absorption of the drug lead to peak plasma levels i...
متن کاملAn Investigation and Comparison of the Effect of Sodium Valproate on Electrophysiological Specificities of the Epileptic and Bipolar Patients
Objective: Patients with epilepsy and with bipolar mood disorder usually are treated with anticonvulsant drugs; and this is due to similar neurological, electrophysiological, and chemical mechanisms, by which both of the disorders can be described. However, these two types of disorders are classified differently under the titles of either neurological or psychiatric disorders. The aim of this ...
متن کاملLack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients
A randomized, double-blind, placebo-controlled cross-over study of adjuvant treatment with remacemide hydrochloride was carried out in 17 patients taking sodium valproate (VPA) as monotherapy. Plasma concentration profiles of VPA, remacemide, and its active desglycinyl metabolite (ARL12495XX) were determined following single (300 mg) and multiple dosing (150 or 300 mg twice daily) of remacemide...
متن کاملEffect of sodium valproate on the sleep structures of epileptic patients
The aims of the present study were to investigate the effect of sodium valproate (VPA) on the sleep structures of epileptic patients and the correlation of these effects with patient weight gain. A total of 60 epileptic patients were divided into three groups: E-AED I (VPA administration for a duration of <3 months), E-AED II (VPA administration for a duration of >3 months) and ECO (without VPA...
متن کاملBone turnover markers in epileptic patients under chronic valproate therapy
BACKGROUND The effects of chronic valproic acid administration on bone health have been a matter of concern and controversy. In this study, the bone status following valproate intake was assessed by using several bone-related biochemical markers. MATERIALS AND METHODS In this case-control study, 62 epileptic patients and 40 age- and gender-matched controls were enrolled. The patients had been...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1978
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1978.tb01663.x